HRID378689

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1140

Toluene

C7H8

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID24386

Thionyl chloride

Cl2OS

HCID12238049

N-(2-METHOXYETHYL)-N-PROPYLAMINE

C6H15NO

结构：Cn1cnc2c1ccn1c(=O)c(-c3ccc(OCc4ccccc4)cc3)cc(C(=O)O)c21

HCID19353611

8-(4-Benzyloxy-phenyl)-3-methyl-7-oxo-3,7-dihydro-imidazo[4,5-a]quinolizine-10-carboxylic acid

C25H19N3O4

PRODUCTS

生成物

结构：CCCN(CCOC)C(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)c(=O)n2ccc3c(ncn3C)c12

HCID56623766

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

From 8-(4-benzyloxy-phenyl)-3-methyl-7-oxo-3,7-dihydro-imidazo[4,5-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene and treatment with triethylamine and (2-methoxy-ethyl)-propyl-amine in dichloromethane.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5a43d07d497c4d6a91b438171d29bb7e
来源数据集: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06030984
来源说明: uspto-grants-2000_02

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:16](=[O:32])[N:17]3C(=C(C(O)=O)[CH:24]=2)[C:21]2[N:28]=[CH:29][N:30]([CH3:31])[C:20]=2[CH:19]=[CH:18]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=S(Cl)Cl.CN(C=[O:41])C.[CH3:42][O:43][CH2:44][CH2:45][NH:46][CH2:47][CH2:48][CH3:49].[C:50]1([CH3:56])C=CC=C[CH:51]=1>ClCCl.C(N(CC)CC)C>[CH3:42][O:43][CH2:44][CH2:45][N:46]([CH2:51][CH2:50][CH3:56])[C:47]([C:48]1[CH:24]=[C:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:14][CH:13]=2)[C:16](=[O:32])[N:17]2[C:49]=1[C:21]1[N:28]=[CH:29][N:30]([CH3:31])[C:20]=1[CH:19]=[CH:18]2)=[O:41]