Hydrochloric Acid → HCID 178433207, compound

HRID 378989Notes

Reaction equation

HRID 378989 reaction equation
[NH:1]([C:5]1[S:6][C:7]([C:11]([NH:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]([O:21]CCCC)=[O:20])=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3].[ClH:26]>>[ClH:26].[NH:1]([C:5]1[S:6][C:7]([C:11]([NH:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]([OH:21])=[O:20])=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178451357HCID 178451357, compound

Product 1

HCID 178433207HCID 178433207, compound

Procedure

151 mg of butyl {3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-propoxy}-acetate are stirred for 5 hrs. in 3 ml of 25% hydrochloric acid. The reaction mixture is evaporated to dryness in a vacuum and the residue is lyophilized from acetic acid. There are obtained 144 mg of [3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-propoxy]-acetic acid hydrochloride (1:1), m.p. 48-51° C., MS: 316 (M+H)+.

Workup

  1. customThe reaction mixture is evaporated to dryness in a vacuum

Sources & evidence

ORD record
ord-cea242e95d754bfdb8fa270b97808cb8
Source dataset
uspto-grants-2001_10
Patent number
US06297266B1

Reaction notes

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