反应详情

温度

80 °C

To a solution of 2-fluoro-4-methylbenzonitrile (356mg, 3.96 mmol) and 3-chlorophenol (439 μL, 4.16 mmol) in 10 mL of DMSO was added Cs2CO3 (2.58 g, 7.92 mmol). The solution was heated at 80° C. for 4 h. The solution was diluted with EtOAc and was washed with Sat. NaHCO3 solution, water, and brine. The organics were dried (MgSO4), filtered, and concentrated in vacuo to give the title compound without further purification.

1. washwas washed with Sat. NaHCO3 solution, water, and brine
2. dry with materialThe organics were dried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated in vacuo