Hydrochloric Acid → 4-[5-(2-Amino-ethyl)-imidazol-1-ylmethyl]-2-fluoro-benzonitrile dihydrochloride

HRID 379057Notes

Reaction equation

HRID 379057 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[N:11]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[C:18]([F:24])[CH:17]=2)[CH:12]=[N:13][CH:14]=1)(C)(C)C.[ClH:26]>CCOC(C)=O>[ClH:26].[ClH:26].[NH2:7][CH2:8][CH2:9][C:10]1[N:11]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[C:18]([F:24])[CH:17]=2)[CH:12]=[N:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54495803{2-[3-(4-cyano-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Product 1

HCID 226271054-[5-(2-Amino-ethyl)-imidazol-1-ylmethyl]-2-fluoro-benzonitrile dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of {2-[3-(4-cyano-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester (1.0 g, 0.0029 mmol) in EtOAc (30 mL) was cooled to −20° C. and saturated with HCl gas. The cooling bath was removed and the reaction was stirred for 2 hr. The solvent was removed in vacuo to obtain the title compound which was used without further purification.

Workup

  1. customThe cooling bath was removed
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1d81d5a8799747b0a65972ae5a951fe1
Source dataset
uspto-grants-2001_10
Patent number
US06297239B1

Reaction notes

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