反应详情

A mixture of 1-6 (50 mg, 0.1847 mmol), 17 (49 mg, 0.1847 mmol) (Rico et al., J. Org. Chem., 1993, 58, 7948), BOP (90 mg, 0.2032 mmol) and NMM (0.122 mL, 1.11 mmol) in CH3CN (2 mL) was stirred for 18 h. The mixture was diluted with ethyl acetate, washed with sat. NaHCO3, brine, and dried over MgSO4. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 20% MeOH/ethyl acetate) to give 1-8 as a yellow oil.

1. washwashed with sat. NaHCO3, brine
2. dry with materialdried over MgSO4
3. customremoval of the solvent
4. customthe residue was chromatographed (silica gel, 20% MeOH/ethyl acetate)