反应详情

Dimethyl (2-oxopropyl)phosphonate (3.1 g,19.1 mmol), anhydrous LiCl (972 mg, 23 mmol), and 3-quinoline carboxaldehyde 6-1 (3.0 g,19.1 mmol) in anhydrous acetonitrile (70 mL), was treated with DBU (2.9 mL, 19.1 mmol) and the resulting suspension stirred at room temperature for 1 h. The solvent was removed at reduced pressure and the resulting residue partitioned between brine and methylene chloride. The organic layer was removed, dried, and concentrated to afford a yellow solid which was recrystallized from ethyl acetate/hexanes to afford 22-1 as an off-white solid.

1. customThe solvent was removed at reduced pressure
2. customthe resulting residue partitioned between brine and methylene chloride
3. customThe organic layer was removed
4. customdried
5. concentrationconcentrated
6. customto afford a yellow solid which
7. customwas recrystallized from ethyl acetate/hexanes