Hydrochloric Acid → HCID 9936973, compound

HRID 379384Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][C:9]=1[N:14]([CH3:34])[C:15]([C:17]1([C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([C:30]([F:33])([F:32])[F:31])[CH:21]=2)[CH2:19][CH2:18]1)=[O:16].Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][C:9]=1[N:14]([CH3:34])[C:15]([C:17]1([C:20]2[CH:25]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:23]=[C:22]([C:30]([F:33])([F:31])[F:32])[CH:21]=2)[CH2:18][CH2:19]1)=[O:16]

Participants

Conditions

Temperature: 0 °C

Procedure

To 125 mg 1-(3,5-bis-trifluoromethyl-phenyl)-cyclopropanecarboxylic acid [4-(2-chlorophenyl)-pyridin-3-yl]-methyl-amide were added 1.5 ml 3 N hydrochloric acid in methanol. After evaporating the solution 3 ml ether were added and the suspension was stirred for 1 h at 0° C. Filtration afforded 100 mg (75%) of the title compound as white crystals. Mp.: 194-196° C.

Workup

customAfter evaporating the solution 3 ml ether
additionwere added
filtrationFiltration

Sources & evidence

ORD record: ord-e9d93dbd88aa42078293c394bdf792b2
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06297375B1

Reaction notes

Loading…