Hydrochloric Acid → HCID 18366841, compound

HRID 379682Notes

Reaction equation

HRID 379682 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([N:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:5][CH:4]=1)#[N:2].Cl.[Cl:24][S:25](O)(=[O:27])=[O:26]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][C:11]([N:13]2[C:22]3[C:17](=[CH:18][C:19]([S:25]([Cl:24])(=[O:27])=[O:26])=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:7][CH:8]=1)#[N:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 24638Chlorosulfonic acidHCID 18366931HCID 18366931, compound

Product 1

HCID 18366841HCID 18366841, compound

Conditions

Temperature
60 °C

Procedure

(0.04 mol) of 1-[3-(4-cyano-phenyl)-propionyl]-1,2,3,4-tetrahydro-quinoline are dissolved in 16 ml of chlorosulphonic acid at 0° C. The thickly liquid mass is heated to 60° C. and hydrochloric acid develops. Then the mixture is carefully added to ice and extracted with methylene chloride, dried and concentrated by rotary evaporation.

Workup

  1. additionThen the mixture is carefully added to ice
  2. extractionextracted with methylene chloride
  3. customdried
  4. concentrationconcentrated by rotary evaporation

Sources & evidence

ORD record
ord-5285b9ba5df04fb09050cbddc416de01
Source dataset
uspto-grants-2001_10
Patent number
US06300342B1

Reaction notes

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