Hydrochloric Acid → HCID 17910543, compound

HRID 379686Notes

Reaction equation

HRID 379686 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([N:14]2[C:23]3[C:18](=[CH:19][C:20]([N:24]([CH2:34][C:35]([O:37]CC)=[O:36])[S:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)(=[O:27])=[O:26])=[CH:21][CH:22]=3)[CH2:17][CH2:16][CH2:15]2)=[O:13])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2].[OH-].[Na+].Cl>C(O)C>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([N:14]2[C:23]3[C:18](=[CH:19][C:20]([N:24]([CH2:34][C:35]([OH:37])=[O:36])[S:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)(=[O:26])=[O:27])=[CH:21][CH:22]=3)[CH2:17][CH2:16][CH2:15]2)=[O:13])=[CH:6][CH:5]=1)(=[NH:2])[NH2:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 17910569HCID 17910569, compound

Product 1

HCID 17910543HCID 17910543, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

370 mg of 1-[3-(4-amidino-phenyl)propionyl]-6-(N-ethoxycarbonylmethyl-phenylsulphonamido)-1,2,3,4-tetrahydro-quinoline are dissolved in 5 ml of ethanol and stirred overnight with 1.6 ml of 1N sodium hydroxide solution. Then the mixture is neutralised with hydrochloric acid, concentrated by evaporation and the residue is chromatographed with methanol over a silica gel column.

Workup

  1. concentrationconcentrated by evaporation
  2. customthe residue is chromatographed with methanol over a silica gel column

Sources & evidence

ORD record
ord-beeaafdc6ad54fd4b0dc957f60bce999
Source dataset
uspto-grants-2001_10
Patent number
US06300342B1

Reaction notes

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