HCID 18367819, compound → HCID 18367823, compound

HRID 379790Notes

Reaction equation

HRID 379790 reaction equation
[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-])=O)[CH:12]=2)[N:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:6]=1[C:22](=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)(=[O:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([NH2:14])[CH:12]=2)[N:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:6]=1[C:22](=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 18367819HCID 18367819, compound

Product 1

HCID 18367823HCID 18367823, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

3-Acetylamino-2-benzoyl-1-(ethoxycarbonyl)-5-nitroindole (Example 96, step 3; 200 mg, 0.51 mmol) was hydrogenolyzed in the presence of palladium on activated carbon (5%, 50 mg) in ethyl acetate (40 ml) at atmospheric pressure for 4 h. Catalyst was removed by filtration and the filtrate was concentrated to afford the title compound.

Workup

  1. customCatalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-b9cafbbd401744a6bd4a339c7690eff0
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

Loading…