Phenacyl bromide → HCID 18367869, compound

HRID 379803Notes

Reaction equation

HRID 379803 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C:7]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:8]=1[C:9]#[N:10])=[O:5])[CH3:2].Br[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19]>C(OCC)(=O)C>[NH2:10][C:9]1[C:8]2[C:7](=[CH:14][CH:13]=[CH:12][C:11]=2[F:15])[N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:17]=1[C:18](=[O:19])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 6259Phenacyl bromideHCID 18368067HCID 18368067, compound

Product 1

HCID 18367869HCID 18367869, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 1 from 2-(ethoxycarbonylamino)-6-fluorobenzonitrile (step 1) and 2-bromoacetophenone. tlc: Rf=0.3 (33% ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-506aa9544ca04e67b71a786f2c107d6a
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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