Phenacyl bromide → HCID 18367847, compound

HRID 379804Notes

Reaction equation

HRID 379804 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C:7]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:8]=1[C:9]#[N:10])=[O:5])[CH3:2].Br[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19]>>[NH2:10][C:9]1[C:8]2[C:7](=[CH:14][C:13]([F:15])=[CH:12][CH:11]=2)[N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:17]=1[C:18](=[O:19])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 6259Phenacyl bromideHCID 18367852HCID 18367852, compound

Product 1

HCID 18367847HCID 18367847, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 1 from 2-(ethoxycarbonylamino)-4-fluorobenzonitrile (step 1) and 2-bromoacetophenone. 1H-NMR (CDCl3) δ: 7.94 (1H, dd, J=2.7, 10.3 Hz), 7.76-7.72 (2H, m), 7.57 (1H, dd, J=5.5, 8.8 Hz), 7.51-7.39 (3H, m), 7.06 (1H, ddd, J=2.7, 8.8, 10.3 Hz), 5.87 (2H, br s), 3.74 (2H, q, J=7.3 Hz), 0.84 (3H, t, J=7.3 Hz)

Sources & evidence

ORD record
ord-9f042256c1864c7ea91d6d42747066b3
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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