Phenacyl bromide → HCID 18367744, compound

HRID 379807Notes

Reaction equation

HRID 379807 reaction equation
[C:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([NH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:4]=1)#[N:2].Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20]>C(OCC)(=O)C>[NH2:8][C:7]1[C:6]2[C:5](=[CH:4][C:3]([C:1]#[N:2])=[CH:10][CH:9]=2)[N:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:18]=1[C:19](=[O:20])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 6259Phenacyl bromideHCID 18367997HCID 18367997, compound

Product 1

HCID 18367744HCID 18367744, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-cyano-2-(ethoxycarbonylamino)benzonitrile (step 1) and 2-bromoacetophenone. tlc: Rf=0.2 (25% ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-ffa41cf2bb0a40d3891e5c76f45e3de3
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

Loading…