Phenacyl bromide → HCID 18367760, compound

HRID 379855Notes

Reaction equation

[CH2:1]([O:3][C:4]([NH:6][C:7]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:8]=1[C:9]#[N:10])=[O:5])[CH3:2].Br[CH2:19][C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:21]>>[NH2:10][C:9]1[C:8]2[C:7](=[CH:14][C:13]([N+:15]([O-:17])=[O:16])=[CH:12][CH:11]=2)[N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:19]=1[C:20](=[O:21])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

Reactant 2

HCID 6259Phenacyl bromide

HCID 18368005HCID 18368005, compound

Product 1

HCID 18367760HCID 18367760, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 1 from 2-(ethoxycarbonylamino)-4-nitrobenzonitrile (step 1) and 2-bromoacetophenone. 1H-NMR (CDCl3) δ: 9.13 (1H, d, J=1.8 Hz), 8.20 (1H, dd, J=1.8, 8.6 Hz), 7.74 (1H, d, J=8.6 Hz), 7.77-7.43 (5H, m), 5.67 (2H, br. s), 3.83 (2H, q, J=7.3 Hz), 0.89 (3H, t, J=7.3 Hz)

Sources & evidence

ORD record: ord-9ecf2f2a0a034c1591abd40e64325695
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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