Hydrochloric Acid → HCID 20693372, compound

HRID 380072Notes

Reaction equation

HRID 380072 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([O:14][C:15](=[O:26])[CH2:16][CH2:17][S:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)([CH3:13])([CH3:12])[CH3:11].Cl>C(N(CC)CC)C>[C:10]([O:14][C:15](=[O:26])[CH2:16][CH2:17][S:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:21][CH:20]=1)([CH3:13])([CH3:11])[CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7412Benzoyl chlorideHCID 20693371HCID 20693371, compound

Product 1

HCID 20693372HCID 20693372, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Triethylamine (3.3 ml) and benzoyl chloride (2.0 ml) were added to the compound prepared in Example 1 and the reaction solution was stirred for 30 minutes at room temperature. 1 N hydrochloric acid was added to the reaction solution. The reaction solution was extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium bicarbonate, water, a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated. The residue was washed with ether to give the title compound (5.17 g).

Workup

  1. extractionThe reaction solution was extracted with ethyl acetate
  2. washThe extract was washed with a saturated aqueous solution of sodium bicarbonate, water
  3. dry with materiala saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate
  4. concentrationconcentrated
  5. washThe residue was washed with ether

Sources & evidence

ORD record
ord-7ca2c0d8d2ea4be9959ce5a3ad0989e9
Source dataset
uspto-grants-2001_10
Patent number
US06300514B1

Reaction notes

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