Oxalyl chloride → HCID 86596519, compound

HRID 380432Notes

Reaction equation

HRID 380432 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14](C(O)=O)[CH:15]=2)[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)[C:22]([Cl:24])=[O:23]>ClCCl.CN(C)C=O>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH3:20])([C:22]([Cl:24])=[O:23])[NH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 22663189HCID 22663189, compound

Product 1

HCID 86596519HCID 86596519, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 1-benzyl-3-methyl-indazole-6-carboxylic acid in dichloromethane (20 ml) was treated with dimethylformamide (2 drops) then with oxalyl chloride (1.69 ml). After stirring for 2 hours the reaction mixture was evaporated and the residue was dried under high vacuum to give the title compound (0.16 g) which was used without further purification.

Workup

  1. customwas evaporated
  2. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-dee3dfb88c734a07abfc2cc9acc856f6
Source dataset
uspto-grants-2001_10
Patent number
US06303600B1

Reaction notes

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