Dimethylamine → HCID 15462363, compound

HRID 380455Notes

Reaction equation

HRID 380455 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:20])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:5](Cl)=[O:6].[CH3:21][NH:22][CH3:23]>O1CCCC1>[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:20])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:5]([N:22]([CH3:23])[CH3:21])=[O:6]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 18349331HCID 18349331, compound

Product 1

HCID 15462363HCID 15462363, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3,5-diiodo-4-(4′-methoxyphenoxy)-N,N-dimethyl benzamide (Compound 9) was prepared way of 3,5-diiodo-4-(4′-methoxyphenoxy)benzoyl chloride (see, Example 1.5). The acid chloride was reacted with excess dimethylamine in tetrahydrofuran at ambient temperature (1 hour), filtered to remove dimethylamine-hydrochloride precipitate, the solvent evaporated and the product crystallized from absolute ethanol.

Workup

  1. filtrationfiltered
  2. customto remove dimethylamine-hydrochloride precipitate
  3. customthe solvent evaporated
  4. customthe product crystallized from absolute ethanol

Sources & evidence

ORD record
ord-746e3b5665cd4e469755e969f6bb78cf
Source dataset
uspto-grants-2001_10
Patent number
US06303621B1

Reaction notes

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