HRID380466

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69873

4-Phenylpiperidine

C11H15N

HCID2759136

4-(4-fluorophenyl)piperidine

C11H14FN

HCID18364719

未命名化合物

PRODUCTS

生成物

HCID2759136

4-(4-fluorophenyl)piperidine

C11H14FN

结构：Fc1ccc(C2CCN(CC3CN(Cc4ccccc4)CC3c3ccsc3)CC2)cc1

HCID18364739

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 1-benzyl-3-(SR)-formyl-4-(RS)-(3-thienyl)pyrrolidine and 4-(4-fluorophenyl)piperidine according to procedures described in Example 1. 4-(4-fluorophenyl)piperidine was prepared according to procedures used to prepare 4-phenylpiperidine in Example 1. Mass Spectrum (CI) m/e 435 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cd7ff1e7caeb485aa6cb7e6a5e5d2108
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06303593B1
来源说明: uspto-grants-2001_10

反应 SMILES

[CH2:1]([N:8]1[CH2:12][CH:11]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[CH:10]([CH:18]=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1.C1(C2CCNCC2)C=CC=CC=1>>[CH2:1]([N:8]1[CH2:12][CH:11]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[CH:10]([CH2:18][N:30]2[CH2:31][CH2:32][CH:27]([C:24]3[CH:23]=[CH:22][C:21]([F:20])=[CH:26][CH:25]=3)[CH2:28][CH2:29]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]2[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]2)=[CH:23][CH:22]=1