4-Phenylpiperidine → 4-(4-Fluorophenyl)piperidine

HRID 380466Notes

Reaction equation

HRID 380466 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[CH:10]([CH:18]=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1.C1(C2CCNCC2)C=CC=CC=1>>[CH2:1]([N:8]1[CH2:12][CH:11]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[CH:10]([CH2:18][N:30]2[CH2:31][CH2:32][CH:27]([C:24]3[CH:23]=[CH:22][C:21]([F:20])=[CH:26][CH:25]=3)[CH2:28][CH2:29]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]2[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]2)=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 698734-PhenylpiperidineHCID 27591364-(4-Fluorophenyl)piperidineHCID 183647191-Benzyl-3-(SR)-formyl-4-(RS)-(3-thienyl)pyrrolidine

Product 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 183647391-Benzyl-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(RS)-(3-thienyl)pyrrolidine

Procedure

The title compound was prepared from 1-benzyl-3-(SR)-formyl-4-(RS)-(3-thienyl)pyrrolidine and 4-(4-fluorophenyl)piperidine according to procedures described in Example 1. 4-(4-fluorophenyl)piperidine was prepared according to procedures used to prepare 4-phenylpiperidine in Example 1. Mass Spectrum (CI) m/e 435 (M+1).

Sources & evidence

ORD record
ord-cd7ff1e7caeb485aa6cb7e6a5e5d2108
Source dataset
uspto-grants-2001_10
Patent number
US06303593B1

Reaction notes

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