反应详情

A solution of 0.2 g (1.22 mmol) of 7-dihydrobenzofuran carboxylic acid, 0.13 g (1.22 mmol) of benzyl alcohol, 0.3 g (2.44 mmol) of DMAP and 0.46 g (2.44 mmol) of 1-[3-(dimethylamino)propyl]-3-ethyl carbodiimide hydrochloride in 5 mL of CH2Cl2 was stirred at rt for 12 h. The reaction mixture was partitioned between CH2Cl2 and water and the pH was adjusted to pH=1 with 1N HCl solution. The reaction mixture was extracted with CH2Cl2 and the combined organic fraction was dried over MgSO4, filtered and the filtrate was concentrated. The residue was purified by chromatography (silica, hexanes: ethyl acetate, 6:1) to give 0.31 g of the title compound.

1. customThe reaction mixture was partitioned between CH2Cl2 and water
2. extractionThe reaction mixture was extracted with CH2Cl2
3. dry with materialthe combined organic fraction was dried over MgSO4
4. filtrationfiltered
5. concentrationthe filtrate was concentrated
6. customThe residue was purified by chromatography (silica, hexanes: ethyl acetate, 6:1)