反应详情

A mixture of 2′-chloro-5′-[3,6-dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4′-fluoroacetanilide (0.85 g, 2.3 mmol), potassium carbonate (0.32 g, 2.3 mmol) and dimethylsulfate (0.22 mL, 2.3 mmol) in tetrahydrofuran is refluxed for 90 minutes, cooled to room temperature, and diluted with water and chloroform. The resultant mixture is concentrated in vacuo to obtain an aqueous suspension which is filtered to give the title product as an off-white solid (0.75 g, mp 257-258.5° C.).

1. temperatureis refluxed for 90 minutes
2. concentrationThe resultant mixture is concentrated in vacuo
3. customto obtain an aqueous suspension which
4. filtrationis filtered