反应详情

温度

60 °C

A mixture of 570 mg 4-(4-chloromethyl-phenylmethoxy)-2-isopropylidenecoumaran-3-one (preparation 2), 240 mg potassium carbonate, 400 mg 4-(4-fluorobenzamido)piperidine and 15 ml dimethylformamide is warmed to 60° C. for 3 hours, then evaporated, mixed with water and extracted with ethyl acetate. After evaporation of the extract, the residue (0.6 g) is purified by silica gel chromatography (eluent ethyl acetate) to give 180 mg (19%) of the desired compound, m.p. 205-208° C.

1. customevaporated
2. additionmixed with water
3. extractionextracted with ethyl acetate
4. customAfter evaporation of the extract
5. customthe residue (0.6 g) is purified by silica gel chromatography (eluent ethyl acetate)