Isopropanol → HCID 57483899, compound

HRID 381695Notes

Reaction equation

HRID 381695 reaction equation
[C:1]([N:4]1[C:8](=[O:9])[CH:7]=[CH:6][C:5]1=[O:10])(=[O:3])[NH2:2].[CH:11]([OH:14])([CH3:13])[CH3:12]>>[C:8]([O:14][CH:11]([CH3:13])[CH3:12])(=[O:9])/[CH:7]=[CH:6]\[C:5](=[O:10])[NH:4][C:1](=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 3776IsopropanolHCID 76868N-Carbamylmaleimide

Product 1

HCID 57483899HCID 57483899, compoundYield 95%

Procedure

The addition of isopropanol to N-carbamylmaleimide under the conditions of Example C afforded a 95% yield of isopropyl maleurate. M.P.: 113°-14° C.; 1H NMR (CDCl3): δ10.6 (br s, 1H), 8.2 (br s, 1H), 6.3 (AB, 2H), 5.8 (br s, 1H), 5.2 (quintet, 1H), 1.3 (d, 6H); HPLC (20% CH3CN/H2O, C8): Rt=5.6 minutes.

Sources & evidence

ORD record
ord-1c1d7e0c86d4471886c48e64e66b1c8a
Source dataset
uspto-grants-2001_10
Patent number
US06307058B1

Reaction notes

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