反应详情

温度

2.5 °C

A suspension of lovastatin (350 g, 0.865 mmol), phenylboronic acid (110.8 g, 0.909 mmol) and toluene (1.75 L) was heated with agitation under a nitrogen atmosphere. A reflux temperature of 100-105° C. was maintained for 55 minutes as water was collected and separated from the reaction mixture. The solution was cooled and 1.39 L of toluene was removed by vacuum distillation at 40-50° C. The concentrated solution was treated with hexanes (3.15 L) between 40-50° C. The resulting suspension was cooled to 0-5° C. for 2 hours and the product was filtered and washed with 0-5° C. hexanes (350 mL). The product was dried at 35-40° C. under vacuum to provide 427.9 g (37%) of lovastatin phenylboronate at >99% purity by HPLC.

1. temperaturewas heated with agitation under a nitrogen atmosphere
2. customwas collected
3. customseparated from the reaction mixture
4. temperatureThe solution was cooled
5. custom1.39 L of toluene was removed by vacuum distillation at 40-50° C
6. additionThe concentrated solution was treated with hexanes (3.15 L) between 40-50° C
7. filtrationthe product was filtered
8. washwashed with 0-5° C. hexanes (350 mL)
9. customThe product was dried at 35-40° C. under vacuum