HRID382202

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID15413

Methyl tert-butyl ether

C5H12O

结构：CNC(=O)[C@@H](NC(=O)C(CC(=O)OC(C)(C)C)c1ccc(-c2ccc(-c3ccccc3)cc2)o1)C(C)(C)C

HCID53815293

未命名化合物

结构：O=C(O)C[C@H](C(=O)N[C@H](CO)Cc1ccccc1)c1ccc(-c2ccc(-c3ccccc3)cc2)o1

HCID54471073

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)[C@@H](NC(=O)C(CC(=O)O)c1ccc(-c2ccc(-c3ccccc3)cc2)o1)C(C)(C)C

HCID18341363

未命名化合物

收率 48%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

According to the procedure described in Example 15(a) for the preparation of N-(1(S)-benzyl-2-hydroxyethyl)-3(S)-(2-biphenyl-4-yl-furan-5-yl)succinamic acid, N-[2,2-dimethyl-1(S)-(methylcarbamoyl)propy]-3-(2-(biphenyl-4-yl)-furan-5-yl)succinamic acid t-butyl ester was deprotected with trifluoroacetic acid in CH2Cl2 after 1 hour. Trituration of crude with MTBE/hex provided in 48% yield N-[2,2-dimethyl-1(S)-(methylcarbamoyl)propyl]-3-(2-(biphenyl-4-yl)-furan-5-yl)succinamic acid as a rust-colored amorphous solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e696ca7391914aa7bd35e533512adcb4
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06306892B1
来源说明: uspto-grants-2001_10

反应 SMILES

C([C@H](NC(=O)[C@H](C1OC(C2C=CC(C3C=CC=CC=3)=CC=2)=CC=1)CC(O)=O)CO)C1C=CC=CC=1.C([O:40][C:41](=[O:73])[CH2:42][CH:43]([C:56]1[O:60][C:59]([C:61]2[CH:66]=[CH:65][C:64]([C:67]3[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=3)=[CH:63][CH:62]=2)=[CH:58][CH:57]=1)[C:44]([NH:46][C@H:47]([C:52](=[O:55])[NH:53][CH3:54])[C:48]([CH3:51])([CH3:50])[CH3:49])=[O:45])(C)(C)C.FC(F)(F)C(O)=O.CC(OC)(C)C>C(Cl)Cl>[CH3:49][C:48]([CH3:51])([CH3:50])[C@H:47]([NH:46][C:44](=[O:45])[CH:43]([C:56]1[O:60][C:59]([C:61]2[CH:62]=[CH:63][C:64]([C:67]3[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=3)=[CH:65][CH:66]=2)=[CH:58][CH:57]=1)[CH2:42][C:41]([OH:73])=[O:40])[C:52](=[O:55])[NH:53][CH3:54]