Cyanoacetic acid → HCID 15907302, compound
Reaction equation
[C:1]([CH2:3]C(O)=O)#[N:2].[C:7]1([CH2:13][CH2:14][C:15](=O)[CH2:16][CH3:17])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[CH2:16]([CH:15]([CH2:14][CH2:13][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][C:1]#[N:2])[CH3:17]Participants
3
Procedure
The reaction was repeated utilizing an equimolar quantity of dimethyl malonate in place of the cyanoacetic acid to yield methyl 4-methyl-5-phenylpentanoate. Repeating the cyanoacetic acid condensation/reduction reaction utilizing 5phenylpentan-3-one as the starting material afforded 3-ethyl-5-phenylpentanenitrile.
Sources & evidence
- ORD record
- ord-e54cbff81cdd4500bae92386282c837c
- Source dataset
- uspto-grants-2001_10
- Patent number
- US06310033B1
Reaction notes
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