反应详情

12.8 g (60 mmol) of 4-benzylideneamino-5-imidazole carboxamide which is an intermediate material obtained in the Reference Example 1 was suspended in a mixed solvent of 240 ml dimethylformamide and 30 ml distilled water, and 16.6 g (120 mmol) of potassium carbonate was added to the suspension. 13.8 ml of benzyl chloride was added dropwise to the solution over 45 minutes at 80° C. After the addition, the mixture was stirred for one hour. The solvent was evaporated under vacuum, the residue was dissolved in chloroform, and the chloroform layer was washed with distilled water. Crude crystals obtained after evaporation of solvent was recrystallized from ethanol to obtain 14.4 g of 4-benzylideneamino-1-benzyl-5-imidazole carboxamide (yield 79%).

1. customobtained in the Reference Example 1
2. additionwas added to the suspension
3. additionAfter the addition
4. customThe solvent was evaporated under vacuum
5. dissolutionthe residue was dissolved in chloroform
6. washthe chloroform layer was washed with distilled water
7. customCrude crystals obtained
8. customafter evaporation of solvent
9. customwas recrystallized from ethanol