Hydrogen Bromide → HCID 135709021, compound

HRID 382379Notes

Reaction equation

HRID 382379 reaction equation
[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:24]C)[CH:19]=3)=[N:12][C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br>C(O)(=O)C>[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[CH:19]=3)=[N:12][C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 1357088767-Benzyl-2-(3-methoxyphenyl)-3,7-dihydro-6H-purin-6-one

Product 1

HCID 135709021HCID 135709021, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

1.00 g (3.01 mmol) of 7-benzyl-2-(3-methoxyphenyl)hypoxanthine prepared according to the same method as in Example 16 was dissolved in 20 ml of acetic acid. 3 ml of hydrobromic acid was added to the solution, followed by stirring for 35.5 hours at 100° C. Crystals obtained by cooling was separated by filtration and washed with distilled water and ethanol. The resulting crude crystals were purified by recrystallization from ethanol to obtain 0.64 g of 7-benzyl-2-(3-hydroxyphenyl)hypoxanthine (yield 67%).

Workup

  1. customCrystals obtained
  2. temperatureby cooling
  3. customwas separated by filtration
  4. washwashed with distilled water and ethanol
  5. customThe resulting crude crystals were purified by recrystallization from ethanol

Sources & evidence

ORD record
ord-c6efbf05fcdb400daf33911c2d8a74c5
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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