Hydrogen Bromide → HCID 135708919, compound

HRID 382382Notes

Reaction equation

HRID 382382 reaction equation
[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13]([C:18]3[CH:23]=[CH:22][C:21]([O:24]C)=[CH:20][CH:19]=3)=[N:12][C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br.C(N(CC)CC)C.O>C(O)(=O)C>[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13]([C:18]3[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=3)=[N:12][C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 962WaterHCID 8471TriethylamineHCID 135709061HCID 135709061, compound

Product 1

HCID 135708919HCID 135708919, compoundYield 39.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

1.52 g (4.57 mmol) of 7-benzyl-2-(4-methoxyphenyl) hypoxanthine prepared by the same method as in Example 14 was dissolved in 25 ml of acetic acid. After the addition of 3 ml of hydrobromic acid, the mixture was stirred for 58.5 hours at 100° C. After cooling, 10 ml of triethylamine and 100 ml of distilled water were added to the reaction mixture. The crystals produced were separated by filtration and washed with distilled water and ethanol to obtain 0.57 g of 7-benzyl-2-(4-hydroxyphenyl)hypoxanthine (yield 39%).

Workup

  1. temperatureAfter cooling
  2. customThe crystals produced
  3. customwere separated by filtration
  4. washwashed with distilled water and ethanol

Sources & evidence

ORD record
ord-61c2bf22b7b1452b9853dce3bf73d11d
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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