Hydrogen Bromide → HCID 135709029, compound

HRID 382383Notes

Reaction equation

HRID 382383 reaction equation
[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24]C)=[N:12][C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br>C(O)(=O)C>[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[OH:24])=[N:12][C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 135708881HCID 135708881, compound

Product 1

HCID 135709029HCID 135709029, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

1.36 g (4.09 mmol) of 7-benzyl-2-(2-methoxyphenyl) hypoxanthine prepared by the same method as in Example 15 was dissolved in 20 ml of acetic acid. After the addition of 3 ml of hydrobromic acid, the mixture was stirred for 35.5 hours at 100° C. After cooling, the produced crystals were separated by filtration and washed with distilled water and ethanol. The crude crystals were purified by suspension in hot ethanol to obtain 0.88 g of 7-benzyl-2-(2-hydroxyphenyl)hypoxanthine (yield 68%).

Workup

  1. temperatureAfter cooling
  2. customthe produced crystals were separated by filtration
  3. washwashed with distilled water and ethanol
  4. customThe crude crystals were purified by suspension in hot ethanol

Sources & evidence

ORD record
ord-5bd6a11fec4a4f5eb9bf555d70b458b4
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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