Picolinic acid → HCID 18360294, compound

HRID 382427Notes

Reaction equation

HRID 382427 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23](O)=[O:24]>>[CH2:10]([N:5]1[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][N:17]=2)=[O:24])[N:3]=[CH:4]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 1018Picolinic acidHCID 140006201-benzyl-4-amino-1H-imidazole-5-carboxamide

Product 1

HCID 18360294HCID 18360294, compoundYield 87%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 1.0 g (4.6 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in the same manner as in Reference Example 2 and picolinic acid instead of 3-pyridylacetic acid hydrochloride to obtain 1.29 g of 1-benzyl-4-(2-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 87%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-acfe422203fb4a639f2cdfb76679e35a
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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