Isonicotinic Acid → 1-Benzyl-4-(4-pyridylcarbonylamino)-5-imidazolecarboxamide

HRID 382428Notes

Reaction equation

HRID 382428 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:17](O)(=[O:24])[C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1>>[CH2:10]([N:5]1[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:17]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)=[O:24])[N:3]=[CH:4]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 5922Isonicotinic AcidHCID 140006201-benzyl-4-amino-1H-imidazole-5-carboxamide

Product 1

HCID 183602571-Benzyl-4-(4-pyridylcarbonylamino)-5-imidazolecarboxamideYield 78%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 19, using 1.00 g (4.62 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in the same manner as in Reference Example 2 and isonicotinic acid instead of cyclopentylacetic acid to obtain 1.16 g of 1-benzyl-4-(4-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 78%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-6d299c58b2a74678a2e81299fb56da18
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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