Isonicotinic Acid → HCID 18360438, compound

HRID 382431Notes

Reaction equation

HRID 382431 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:18](O)(=[O:25])[C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[O:25])[N:3]=[CH:4]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 5922Isonicotinic AcidHCID 18360275HCID 18360275, compound

Product 1

HCID 18360438HCID 18360438, compoundYield 65%

Procedure

An amidation reaction and post-treatment were carried out under the same conditions as in Example 19, using 2.0 g (8.5 mmol) of 4-amino-1-(4-fluorobenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 58 and isonicotinic acid instead of cyclopentylacetic acid to obtain 1.87 g of 1-(4-fluorobenzyl)-4-(4-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 65%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-3e4dce3662834bdf8a3f78918785cd9b
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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