反应详情

温度

200 °C

A mixture of 4-cyano-2-nitroaniline (10.8 g, 66 mmol), 2-bromopyridine (12.6 g, 80 mmol), anhydrous potassium carbonate (9.12 g, 66 mmol) and copper-bronze (1.0 g, 15.7 mmol) in nitrobenzene (100 ml) was heated overnight at 200° C. The reaction mixture was cooled and filtered through a pad of celite. The filter cake was washed with dichloromethane (500 ml) and the filtrate was evaporated. The resultant residue was purified by column chromatography (silica gel, 500 g; n-hexane/ethyl acetate/dichloromethane (4/1/1)) to afford 7.28 g (46%) of 4-cyano-2-nitro-N-(2-pyridyl)aniline as orange solids.

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered through a pad of celite
3. washThe filter cake was washed with dichloromethane (500 ml)
4. customthe filtrate was evaporated
5. customThe resultant residue was purified by column chromatography (silica gel, 500 g; n-hexane/ethyl acetate/dichloromethane (4/1/1))