Dichloromethane → HCID 131722915, compound

HRID 382642Notes

Reaction equation

HRID 382642 reaction equation
ClCCl.[I-].[Cl:5][C:6]1[N:7](C)[CH:8]=[N+:9]2[CH:13]=[C:12]([C:14]3[CH2:15][C@@H:16]4[C@@H:33]([C@H:34]([OH:36])[CH3:35])[C:32](=[O:37])[N:17]4[C:18]=3[C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=3)=[O:20])[S:11][C:10]=12>CN(C=O)C>[Cl:5][C:6]1[N:7]=[CH:8][N:9]2[CH:13]=[C:12]([C:14]3[CH2:15][C@@H:16]4[C@@H:33]([C@H:34]([OH:36])[CH3:35])[C:32](=[O:37])[N:17]4[C:18]=3[C:19]([O:21][CH2:22][C:23]3[CH:24]=[CH:25][C:26]([N+:29]([O-:31])=[O:30])=[CH:27][CH:28]=3)=[O:20])[S:11][C:10]=12

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 131722916HCID 131722916, compound

Product 1

HCID 131722915HCID 131722915, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same manner as in Example 4-a) except that 98 mg of 4-nitrobenzyl (5R,6S)-2-(7-chloroimidazo[5,1-b]thiazol-2-yl)-6-((1R)-1-hydroxyethyl)-1-carbapen-2-em-3-carboxylate and a mixed solvent of dichloromethane and DMF (1:1), the crude 4-nitrobenzyl (5R,6S)-2-(7-chloro-6-methylimidazo[5,1-b]thiazolium-2-yl)-6-((1R)-1-hydroxyethyl)-1-carbapen-2-em-3-carboxylate iodide was obtained as a yellowish brown oil in a yield of 99 mg.

Sources & evidence

ORD record
ord-f9845ecfd57a4b2e9e6c6b4cc83db980
Source dataset
uspto-grants-2001_10
Patent number
US06310056B1

Reaction notes

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