HCID 86631064, compound → (Cis)-[4-chloro-2-[[2,3-dimethyl-4-(phenylacetyl)-1-piperazinyl]methyl]phenoxy]-acetic Acid

HRID 38282Notes

Reaction equation

HRID 38282 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8]([O:10]C(C)(C)C)=[O:9])=[C:4]([CH2:17][N:18]2[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@H:20]([CH3:33])[C@@H:19]2[CH3:34])[CH:3]=1>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:17][N:18]2[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@H:20]([CH3:33])[C@@H:19]2[CH3:34])[CH:3]=1

Participants

3

Reactant 1

HCID 86631064HCID 86631064, compound

Product 1

HCID 67131752(Cis)-[4-chloro-2-[[2,3-dimethyl-4-(phenylacetyl)-1-piperazinyl]methyl]phenoxy]-acetic Acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The product from example 71 part b) treated with TFA (10 ml) for 16 h. Concentration in vacuo and purification by RPHPLC gave the title product as a white foam (39 mg).

Workup

  1. concentrationConcentration
  2. customin vacuo and purification by RPHPLC

Sources & evidence

ORD record
ord-be08dd6f876d4af3aa0f440e528cfbe8
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Reaction notes

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