Piconol → HCID 18361715, compound

HRID 382927Notes

Reaction equation

[CH2:1]([C:3]1[O:7][N:6]=[C:5]([C:8]2[N:12]3[N:13]=[C:14]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)[C:15]4[C:20]([C:11]3=[N:10][N:9]=2)=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:4]=1)[CH3:2].N1C=CC=CC=1CO>>[CH3:2][C:1]1[C:5]([C:8]2[N:12]3[N:13]=[C:14]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)[C:15]4[C:20]([C:11]3=[N:10][N:9]=2)=[CH:19][CH:18]=[CH:17][CH:16]=4)=[N:6][O:7][C:3]=1[CH3:4]

Participants

Reactant 2

HCID 11474Piconol

HCID 18361791HCID 18361791, compound

Product 1

HCID 18361715HCID 18361715, compound

Procedure

The title-compound was prepared from 6-chloro-3-(4,5-dimethylisoxazol-3-yl)-1,2,4-triazolo[3,4-a]phthalazine prepared in Example 32 part a and 2-pyridylcarbinol using the procedure given for Example 1, 1H NMR (360 MHz, CDCl3) δ 2.30 (3H, s, Me), 2.49 (3H, s, Me), 5.73 (2H, s, CH2O), 7.29 (1H, m, Ar—H), 7.70-7.83 (3H, m, 3 of Ar—H), 7.96 (1H, m, Ar—H), 8.31 (1H, d, J=8.3 Hz, Ar—H, 8.64-8.70 (2H, m, 2 of Ar—H); MS (ES+) m/e 373 [MH]+; Anal. Found C, 64.38; H, 4.05; N,22.60. C20H16N6O2 requires C, 64.50; H, 4.33; N, 22.57%.

Sources & evidence

ORD record: ord-35f002d2e1924e88bfe4ef57785cb3b5
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310203B1

Reaction notes

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