反应详情

2M HCl (50 ml) was added drop wise to a solution of the product of part (b) (31.8 g) in ethanol (1500 ml), the reaction was stirred for 1.5 h. Solid sodium hydrogen carbonate (8.4 g) was added and stirred for 1 h, then concentrated in vacuo. The residue was purified by chromatography (silica, 0-2-5% MeOH/DCM as eluent) to remove the by-products, then eluted with 10% MeOH/DCM to give the sub-title compound (9.3 g).

1. stirringstirred for 1 h
2. concentrationconcentrated in vacuo
3. customThe residue was purified by chromatography (silica, 0-2-5% MeOH/DCM as eluent)
4. customto remove the by-products
5. washeluted with 10% MeOH/DCM