反应详情

温度

80 °C

3,5-Dihydroxybenzoic acid (15.0 g, 97.3 mmol) and potassium carbonate (44.0 g, mol) were mixed in N,N-dimethylformamide (60 ml) and heated to 80° C. Allyl bromide (42.0 g, 0.35 mol) was added dropwise during 1 h and efficient stirring was continued for 24 h. The reaction mixture was then evaporated to a semisolid residue, which was treated with chloroform (500 ml) and filtered. The filtrate was washed with water (3×150 ml), dried (Na2SO4) and filtered through a short column of alumina. Evaporation of the solvent gave 23.1 g (87%) of the product as a colorless oil.

1. customThe reaction mixture was then evaporated to a semisolid residue, which
2. additionwas treated with chloroform (500 ml)
3. filtrationfiltered
4. washThe filtrate was washed with water (3×150 ml)
5. dry with materialdried (Na2SO4)
6. filtrationfiltered through a short column of alumina
7. customEvaporation of the solvent