反应详情

Ammonium acetate (5.6 g, 72.73 mmol, 1.00 equiv) was added to a solution of 3,4-dihydroxybenzaldehyde (10 g, 72.41 mmol, 1.00 equiv) and nitromethane (50 mL). The resulting mixture was heated at reflux for about 16 hours, and then concentrated in vacuo. The resulting residue was then purified by silica gel column chromotagraphy (ethyl acetate/petroleum ether (1:5)) to give the title compound as a yellow oil (8 g, yield=61%).

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for about 16 hours
3. concentrationconcentrated in vacuo
4. customThe resulting residue was then purified by silica gel column chromotagraphy (ethyl acetate/petroleum ether (1:5))