Potassium Carbonate → HCID 66977868, compound

HRID 383252Notes

Reaction equation

HRID 383252 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].C(=O)([O-])[O-].[K+].[K+].[CH3:19][S:20]([N:23]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]2[S:38][C:37]3[C:36]([N:39]4[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)=[N:35][C:34]([C:45]4[CH:53]=[CH:52][CH:51]=[C:50]5[C:46]=4[CH:47]=[N:48][N:49]5CCCCC(OCC)=O)=[N:33][C:32]=3[CH:31]=2)[CH2:25][CH2:24]1)(=[O:22])=[O:21].[CH3:63][S:64]([N:67]1[CH2:72][CH2:71][N:70]([CH2:73][C:74]2[S:82][C:81]3[C:80]([N:83]4[CH2:88][CH2:87][O:86][CH2:85][CH2:84]4)=[N:79][C:78]([C:89]4[C:90]5[C:94]([CH:95]=[CH:96][CH:97]=4)=[N:93][N:92]([CH2:98]CCCC(OCC)=O)[CH:91]=5)=[N:77][C:76]=3[CH:75]=2)[CH2:69][CH2:68]1)(=[O:66])=[O:65]>C(#N)C>[CH3:19][S:20]([N:23]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]2[S:38][C:37]3[C:36]([N:39]4[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)=[N:35][C:34]([C:45]4[CH:53]=[CH:52][CH:51]=[C:50]5[C:46]=4[CH:47]=[N:48][N:49]5[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:33][C:32]=3[CH:31]=2)[CH2:25][CH2:24]1)(=[O:21])=[O:22].[CH3:63][S:64]([N:67]1[CH2:68][CH2:69][N:70]([CH2:73][C:74]2[S:82][C:81]3[C:80]([N:83]4[CH2:84][CH2:85][O:86][CH2:87][CH2:88]4)=[N:79][C:78]([C:89]4[C:90]5[C:94]([CH:95]=[CH:96][CH:97]=4)=[N:93][N:92]([CH2:98][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:91]=5)=[N:77][C:76]=3[CH:75]=2)[CH2:71][CH2:72]1)(=[O:65])=[O:66]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 122490Ethyl 7-bromoheptanoateHCID 66977641HCID 66977641, compoundHCID 66977722HCID 66977722, compound

Product 2

HCID 66977868HCID 66977868, compoundYield 27%HCID 67146620HCID 67146620, compoundYield 16%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound 0115-5 (110 mg, 27%) and 0116-5 (60 mg, 16%) were prepared from 0114 (280 mg, 0.55 mmol) , ethyl 7-bromoheptanoate (133 mg, 0.65 mmol) and potassium carbonate (152 mg, 1.10 mmol) in acetonitrile (25 mL) using a procedure similar to that described for compound 0115-3 and compound 0116-3 (Example 1):

Sources & evidence

ORD record
ord-360108300bf6452d9f8e4c75660e8a46
Source dataset
uspto-grants-2013_02
Patent number
US08367663B2

Reaction notes

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