反应详情

(2-Isopropyl-4,5-dimethoxy-benzylidene)-(1-isopropyl-2-methyl-propyl)-amine was dissolved in 30 ml of THF. HCl (4.1 mL, 4 M) was added and the mixture was warmed to reflux. After 3 hours the mixture was cooled concentrated in vacuo. 100 mL of H2O was added and the mixture was extracted with ethyl acetate, washed with H2O and then with brine. The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to give an orange oil. Purification via flash chromatography (85:15 hexane/ethyl acetate) gave 2-isopropyl-4,5-dimethoxy-benzaldehyde (0.331 g, 43%) as a clear oil

1. temperaturethe mixture was warmed to reflux
2. temperatureAfter 3 hours the mixture was cooled
3. concentrationconcentrated in vacuo
4. addition100 mL of H2O was added
5. extractionthe mixture was extracted with ethyl acetate
6. washwashed with H2O
7. dry with materialThe combined organic layers were dried over Na2SO4
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customto give an orange oil
11. customPurification via flash chromatography (85:15 hexane/ethyl acetate)