反应详情

温度

0 °C

7-Chloro-imidazo-[1,2-a]-pyridine (1 eq, 38.9 mmol, 5.93 g) is dissolved in DMF (20 ml) at 0° C. and NBS (1.1 eq, 42.8 mmol, 7.61 g) is added. The reaction mixture is stirred for 1 h at 0° C. and is diluted with EtOAc. The reaction mixture is washed with NaHCO3 and brine, dried over MgSO4, filtered and evaporated. The product is purified by flash column chromatography eluting with 8:2 DCM/MeOH to afford 3-bromo-7-chloro-imidazo-[1,2-a]-pyridine as a brown solid; [M+H]+=232

1. washThe reaction mixture is washed with NaHCO3 and brine
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. customevaporated
5. customThe product is purified by flash column chromatography
6. washeluting with 8:2 DCM/MeOH