HCID 59406763, compound → HCID 59406652, compound

HRID 383638Notes

Reaction equation

HRID 383638 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-])=O)[CH:21]=3)=[N:14]2)[CH:7]=1)[CH3:2]>C1COCC1.[Ni]>[CH2:1]([O:3][C:4](=[O:29])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([NH2:26])[CH:21]=3)=[N:14]2)[CH:7]=1)[CH3:2]

Participants

4

Reactant 1

HCID 59406763HCID 59406763, compound

Product 1

HCID 59406652HCID 59406652, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

1 g (2.5 mmol) of ethyl{3-[3-(3-nitrophenyl)-6-oxo-6H-pyridazin-1-yl-methyl]phenyl}carbamate are dissolved in 10 ml of THF, 1 g of Raney nickel is added, and the mixture is hydrogenated at room temperature for 6 h under a hydrogen atmosphere. The reaction mixture is filtered, the filter residue is rinsed with THF, and the filtrate is evaporated to dryness.

Workup

  1. filtrationThe reaction mixture is filtered
  2. washthe filter residue is rinsed with THF
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-69779d3d8d5b45289e8ab7b82f7c5e62
Source dataset
uspto-grants-2013_02
Patent number
US08367668B2

Reaction notes

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