反应详情

Under a nitrogen atmosphere, 38 mg (0.11 mmol) of 4-(6-oxo-1,6-dihydropyridazin-3-yl)-N-(3-piperidin-1-ylpropyl)benzamide are suspended in 1 ml of THF, and 27 mg (0.18 mmol) of (1H-indazol-5-yl)methanol and 88 mg (0.34 mmol) of triphenyphosphine are added. 53 μl (0.34 mmol) of diethyl azodicarboxylate was added dropwise to this suspension at 2-10° C. with ice-cooling. The suspension was stirred at room temperature for 15 h. The reaction mixture was evaporated and purified by means of preparative HPLC.

1. temperaturecooling
2. customThe reaction mixture was evaporated
3. custompurified by means of preparative HPLC