反应详情

温度

75 °C

23 g of 2-Bromo-4,6-bis-(4-fluoro-3-trifluoromethyl-phenoxy)-pyrimidin-5-ylamine are dissolved under nitrogen together with 10.7 g of 3-(N,N-dimethylamino)phenylboronic acid, 0.4 g of tris(dibenzylideneacetone)dipalladium, 27.5 g of K3PO4 and 0.7 g of 2-dicyclohexyl-phosphino-2′,6′-dimethoxybiphenyl in 450 ml of toluene. The mixture is heated at 75° C. for 24 h, diluted with diethylether, washed with water and then dried over MgSO4. The solvents are removed under vacuum. 14.8 g of the title compound are isolated as white powder (mp. 110-111° C.) after purification by filtration and recrystallization from cyclohexane.

1. washwashed with water
2. dry with materialdried over MgSO4
3. customThe solvents are removed under vacuum