Water → HCID 58196499, compound

HRID 383695Notes

Reaction equation

HRID 383695 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH:11]=[O:12])=[C:4]2[N:3]=1.[O:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]2[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=2)[NH2:23])[CH2:15][CH2:14]1.O>CN(C=O)C>[O:13]1[CH2:14][CH2:15][N:16]([CH2:19][C:20]2[CH:21]=[C:22]([NH:23][C:2]3[CH:7]=[CH:6][N:5]4[N:8]=[CH:9][C:10]([CH:11]=[O:12])=[C:4]4[N:3]=3)[CH:24]=[CH:25][CH:26]=2)[CH2:17][CH2:18]1

Participants

5

Reactant 3

HCID 962WaterHCID 10964063-(Morpholin-4-ylmethyl)anilineHCID 581964015-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde

Product 1

HCID 58196499HCID 58196499, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
140 °C

Procedure

To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (30 mg, 0.166 mmol) in DMF was added 3-(morpholinomethyl)aniline (233 mg, 1.213 mmol). The mixture was heated in microwave for 40 minutes at 140° C. Water was added and the solid formed was isolated by filtration to yield 5-(3-(morpholinomethyl)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde. LCMS (M+1=338)

Workup

  1. customthe solid formed
  2. customwas isolated by filtration

Sources & evidence

ORD record
ord-3659a7c95bc4438eaaaf5ce99f1d1468
Source dataset
uspto-grants-2013_02
Patent number
US08367681B2

Reaction notes

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