Hydrochloric Acid → HCID 178469253, compound

HRID 383714Notes

Reaction equation

HRID 383714 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH:6]([C:10]([CH3:12])=O)[C:7]([CH3:9])=O)=[O:5].[NH2:13][C:14]([NH2:16])=[O:15].Cl>C(O)C>[OH:15][C:14]1[N:16]=[C:10]([CH3:12])[C:6]([C:4]([O:3][CH2:2][CH3:1])=[O:5])=[C:7]([CH3:9])[N:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1176UreaHCID 79063Ethyl 2-acetylacetoacetate

Product 1

HCID 178469253HCID 178469253, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of ethyl diacetoacetate (17.22 g, 100 mmol), urea (9.61 g, 160 mmol) and HCl (10 M, 4 ml) in ethanol (400 ml) was heated to 90° C. for 12 hours. The mixture was concentrated to remain 200 ml and then was cooled to −20° C. to allow precipitation. The mixture was filtered at room temperature to obtained 6a as solid granulate (5.32 g, 2.71 mmol, 27%).

Workup

  1. concentrationThe mixture was concentrated
  2. temperaturewas cooled to −20° C.
  3. customprecipitation
  4. filtrationThe mixture was filtered at room temperature

Sources & evidence

ORD record
ord-49332fd55488466f9782105169caccf0
Source dataset
uspto-grants-2013_02
Patent number
US08367684B2

Reaction notes

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