Hydrochloric Acid → HCID 86661359, compound

HRID 383785Notes

Reaction equation

HRID 383785 reaction equation
[N:1]([C@@H:4]1[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][C@@H:6]([C:17]([O:19][CH3:20])=[O:18])[CH2:5]1)=[N+:2]=[N-:3].[ClH:21]>CO>[ClH:21].[N:1]([C@H:4]1[CH2:9][NH:8][CH2:7][C@@H:6]([C:17]([O:19][CH3:20])=[O:18])[CH2:5]1)=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86661361HCID 86661361, compound

Product 1

HCID 86661359HCID 86661359, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To the solution of 1-tert-butyl 3-methyl trans-5-azidopiperidine-1,3-dicarboxylate (343.0 mg) in MeOH (1 ml) was added 10% solution of HCl in MeOH (15 ml). After stirring for 30 minutes at room temperature, the mixture was concentrated to give the crude methyl cis-5-azidopiperidine-3-carboxylate hydrochloride (120.3 mg) as a pale brown solid.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-5f351b91bcba4ccba7fc8db415d07ff1
Source dataset
uspto-grants-2013_02
Patent number
US08367690B2

Reaction notes

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