Hydrochloric Acid → HCID 59291346, compound

HRID 383911Notes

Reaction equation

HRID 383911 reaction equation
[C:1]1([C:7]2[S:11][C:10]3[CH2:12][CH2:13][CH2:14][C:9]=3[C:8]=2[C:15]([O:17]C)=[O:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CCO>[C:1]1([C:7]2[S:11][C:10]3[CH2:12][CH2:13][CH2:14][C:9]=3[C:8]=2[C:15]([OH:17])=[O:16])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59291511HCID 59291511, compound

Product 1

HCID 59291346HCID 59291346, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of methyl 2-phenyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate in EtOH was added a 1 M aqueous NaOH solution, followed by heating under reflux for 5 hours. The reaction mixture was adjusted into pH=2 by addition of 1 M hydrochloric acid, and the solid precipitated was collected by filtration, and washed with water to obtain 2-phenyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid as a white solid.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 5 hours
  3. customthe solid precipitated
  4. filtrationwas collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-9779c65e72fa4dd8957d8f22144dc374
Source dataset
uspto-grants-2013_02
Patent number
US08367696B2

Reaction notes

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