HCID 86641944, compound → HCID 178515868, compound

HRID 384125Notes

Reaction equation

HRID 384125 reaction equation
O[NH:2][C:3](=[O:29])[CH2:4][C:5](=[O:28])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:9][CH:8]=1>C(O)(=O)C.Cl>[O:21]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][C:5]2[O:28][N:2]=[C:3]([OH:29])[CH:4]=2)=[CH:8][CH:9]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 1

HCID 86641944HCID 86641944, compound

Product 1

HCID 178515868HCID 178515868, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

To a solution of N-hydroxy-3-oxo-4-(4-((2-phenoxybenzyl)oxy)phenyl)butanamide (17.2 mg) in acetic acid (0.2 ml), 0.05 ml of concentrated hydrochloric acid was added, and the reaction solution was stirred overnight at room temperature. The solvent was distilled off under reduced pressure, and the residue obtained was purified by preparative thin layer chromatography (Kieselgel™ 60 F254, Art5744, made by Merck & Co., hexane/ethyl acetate (1:1) to afford the title compound as a yellow oil.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue obtained
  3. customwas purified by preparative thin layer chromatography (Kieselgel™ 60 F254, Art5744

Sources & evidence

ORD record
ord-8537372c91304d5881a9630d28a0b30f
Source dataset
uspto-grants-2013_02
Patent number
US08367708B2

Reaction notes

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